| 3012 Heritability Estimates for Laser Fluorescence Measurements in the Primary Dentition of Twins | ||
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W. BRETZ1, P. CORBY2, M. MELO FILHO3, M.Q. COELHO3, S.M. COSTA3, M.M. VANYUKOV1, P.S. HART1, R.J. WEYANT1, M.L. MARAZITA1, and T.C. HART1, 1 University of Pittsburgh, PA, USA, 2 University of Pittsburgh and Harvard University, PA, USA, 3 Unimontes, Montes Claros, Brazil Objective: By utilizing a twin model, to determine the contribution of genetic and environmental factors to dental caries measured with a laser fluorescence system. Methods: Infra-red laser fluorescence (ILF) (DiagnodentTM, KAVO, Germany) measurements were performed on 322 pairs of twins 1.5 to 7 years old ascertained from a government-based registry in the city of Montes Claros, Brazil. 91 % of the twins had never visited a dentist. Genotyping 8 polymorphic DNA markers determined zygosity. Twins had their teeth thoroughly cleaned prior to exams. Surfaces examined included the buccal and lingual of maxillary central incisors and the occlusal of all molars of the primary dentition. Those surfaces were selected because they are representative of early childhood caries. The maximum value of ILF for each surface (possible range of 0 to 30) was recorded. Structural equation modeling estimated ILF phenotypic variance components using Mx software (ACE analysis). Results: A dominant genetic component was present at the occlusal surface of tooth 84 (0.45, p=.63) but was not significant. ILF measurements for the occlusal surface of tooth 54 were significantly correlated between monozygotic twins (0.23, p=.026) indicating the presence of a dominant genetic component to dental caries, while the correlations between dizygotic twins were not (0.04, p<.10). Preliminary analysis revealed high correlations for ILF measurements on the lingual surface of tooth 51. However, when ACE analysis was performed familiality was observed for the lingual surface of tooth 51 (twin values were uncorrelated), suggesting a more significant role of the environment on dental caries as measured by the ILF system. Conclusion: These findings suggest that a genetic contribution to caries occurrence on tooth and surface-specific locations is apparent and may direct research on candidate genes for dental caries surface-specific traits. Supported by NIH/NIDCR grants DE13534 and DE12879 | ||
| Seq #304 - Caries Epidemiology in Children 3:45 PM-5:45 PM, Saturday, 28 June 2003 Svenska Massan F4 | ||
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