| 2947 Improving Implant Integration of Early-loaded Implants by Controlled Mechanical Stimulation: An Animal Experimental Study | ||
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E. DE SMET1, S.V.N. JAECQUES1, J.A. JANSEN2, M. WEVERS1, J. VANDERSLOTEN1, G. VAN DER PERRE1, and I.E. NAERT1, 1 Katholieke Universiteit Leuven, Belgium, 2 University of Nijmegen, Netherlands Objective: Aim of this study was to investigate whether early loading can favour bone response and the integration of percutaneous implants. Methods: Percutaneous titanium implants (IPI, Steri-Oss®, Nobel Biocare, Sweden / MTI, Dentatus AB, Sweden) were placed in both tibiae of guinea pigs. With an electromechanical shaker (Model 4810, Brüel and Kjaer, Naerum, Denmark), implants were mechanically stimulated with a sinusoidally varying bending moment for 1800 cycles. Three series (n≥6) received low amplitude/high frequency stimulation (0.5N, 1N, 1.5 N/30Hz), another 3 series received high amplitude/low frequency stimulation (2N, 3N, 4N/3Hz). Daily stimulation was applied unilaterally during 4 weeks, starting one week post-operatively. The contra-lateral leg was used as control. Bone(re)modelling of both implants was followed by in vivo (1 week post-op and two weeks after loading) and post mortem micro-focus computer tomography (Philips microfocus X-ray source (HOMX161) with AEA Tomohawk rotating CT sample stage and software). The slices were scored on a 0 to 5 scale for the parameters: area of newly formed bone and level of osseointegration. The scores of the stimulated and control leg were compared with a non-parametric test. The protocols were approved by the ethical committee of the animal research facility of the KULeuven. Results: 2 of 6 test implants of the 4N/30Hz series were tested clinically mobile. For the low amplitude/high frequency series, micro-ct slices showed a significantly better score for the examined parameters for the test side in comparison with the control side (p<0.005). Conclusions: The effect of controlled mechanical stimulation on the bone response of immediately loaded percutaneous implants in the tibia of guinea pigs was demonstrated semi-quantitatively by in vivo microfocus CT. At present; it is not yet possible to discriminate the effect of the different stimulation parameters; this will be quantified histomorphometrically. Supported by VIS/99/012 grant ‘IMFIX', K.U.Leuven Research Council/Flemish Government. | ||
| Seq #295 - Bone Response to Surfaces/Scaffolds 1:30 PM-3:30 PM, Saturday, 28 June 2003 Svenska Massan J2 | ||
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