The Effect of GTR in Combination with Deproteinized Bovine Bone and/or Enamel Matrix Proteins on the Augmentation of the Mandible

*1168 The Effect of GTR in Combination with Deproteinized Bovine Bone and/or Enamel Matrix Proteins on the Augmentation of the Mandible*
N. DONOS¹, L. KOSTOPOULOS², M. TONETTI¹, F. GRAZIANI¹, A. SCULEAN³, A. STAVROPOULOS², D. BOSSHARDT⁴, T. KARRING², and N. LANG⁴, ¹ Eastman Dental Institute for Oral Health Care Sciences, London, United Kingdom, ² Royal Dental College, University of Aarhus, Aarhus C, Denmark, ³ University of Saarland, Homburg, Germany, ⁴ University of Berne, Switzerland Objective: To evaluate whether the use of enamel matrix proteins with or without the use of deproteinized bovine bone influences bone formation when used as an adjunct to Guided Tissue Regeneration (GTR). Methods: Twenty rats, divided in 4 groups of 5 animals each were used in this study. Group A1: A hemispherical PTFE-capsule was placed with its opening facing the lateral aspect of the mandibular ramus. At the contralateral side of the jaw, the capsule was filled with an enamel matrix derivative (EMD) before its placement to the lateral surface of the ramus. The healing period was 60 days. Group A2: The animals were treated in the same manner as in group A1 but with a healing period of 120 days. Group B1: The animals were treated in the same manner as in group A1 with the difference that deproteinized bovine bone particles (DBB) were also loosely packed in the capsule. At the contralateral side of the jaw, the capsule was filled with a mixture of EMD and DBB. The healing period was 60 days. Group B2: The same treatment as in B1 but with a healing period of 120 days. Results: The histological analysis revealed that in groups A1 and A2, newly formed bone was covering a significant part of the empty capsules (GTR). The use of EMD in the capsule did not offer any added benefit to the use of the capsule alone in terms of new bone formation. At groups B1 and B2, the presence of DBB and/or EMD did not increase the amount of newly formed bone under the capsules either. Conclusion: The use of EMD and/or DBB as an adjunct to GTR does not offer any added effect in new bone formation. Supported by the International Team for Oral Implantology, ITI Foundation Research Committee.
Seq #123 - GTR and New Bone Grafting Materials 3:45 PM-5:00 PM, Thursday, 26 June 2003 Svenska Massan Exhibition Hall B
Back to the Periodontal Research - Therapy Program Back to the 81st General Session of the International Association for Dental Research (June 25-28, 2003)
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