Objective: The aim of this study was to evaluate the clinical efficacy of two commercially available self-applied tooth whiteners over a 21 day usage period. Methods: A total of 38 subjects were randomised to Colgate® Simply White^TM, an 18% carbamide peroxide paint-on liquid in an applicator bottle, or Crest® Night Effects^TM, a 19% sodium percarbonate bleaching film in unit dose sachets. Study participants were supplied with manufacturers written instructions for use, Colgate® Simply White^TM was used twice daily for 30 minutes and Crest® Night Effects^TM was used once a day, overnight. Study duration was 21 days. Efficacy and safety measurements at baseline and 21 days comprised of oral soft tissue examinations and digital image analysis (DIA). Whitening efficacy was determined by evaluating changes from baseline in tooth yellowness (Db*) and tooth brightness (DL*). Statistical analysis was by ANCOVA. Results: After 21 days both treatments showed a significant reduction in tooth yellowness and significant increase in tooth brightness (p£0.0003). Crest® Night Effects^TM giving a Db* of –1.53 and a DL* of 1.28 and Colgate® Simply White^TM giving a corresponding Db* of – 0.46 and a DL* of 0.78. Between group comparisons showed significant (p<0.05) greater colour improvements for 19% percarbonate bleaching film compared to 18% carbamide peroxide liquid. Both treatments were well tolerated. Conclusion: Crest® Night Effects^TM provided superior whitening compared to Colgate® Simply White^TM over three weeks use.

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