| 2943 Bone Regeneration around Implants with Bone Growth Factor rhGDF-5 | ||
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D. WENG1, O. ZUHR2, M. BELL1, E.-J. RICHTER1, and M.B. HÜRZELER2, 1 University of Würzburg, Germany, 2 Private Practice, München, Germany Bone-deficient sites can be regenerated simultaneously with implant placement. Barrier membranes maintain the necessary space and protect the site from soft tissue ingrowth. Recently, growth factors have been used to improve regeneration. Objectives: It was the purpose of this animal study to histometrically evaluate bone regeneration around implants with and without a bone growth factor (rhGDF-5). Methods: In 6 beagle dogs, all mandibular premolars were extracted. Two months later, bucco-lingual saddle defects of critical size were created, and a screw-type implant (2x10mm) was placed into each defect center. Thus the coronal half of the implant was free-standing in the defect. One defect was filled with ?-tricalciumphosphate, which was coated with 300∝g rhGDF-5/g ß-TCP and then covered with a titanium-reinforced ePTFE-membrane (GDF group). The second defect received the same treatment but without the rhGDF-5 (MEM group). A third defect with implant was left untreated (CON group). The flaps were closed over the defects and histology was made 2 months later. Histometrically, the total new bone area and the regenerated bone height (with and without first implant contact), expressed as percentage, were assessed. Results: All implants were histologically osseointegrated. In the MEM group, one membrane became exposed and one defect could not be evaluated. Total new bone area for GDF, MEM and CON was 46.9±17.9mm2, 30.6±19.2mm2, 10.0±5.2mm2. Total regenerated bone height (reference:implant top) was 126.5±32.1%, 94.3±37.1%, 50.4±13.8%. Regenerated bone height in contact with the implant surface (reference:first implant thread) was 142.9±55.5%, 43.7±27.6%, 73.8±21.8%). GDF was significantly better than CON (for all parameters; p<0.05, ANOVA) and MEM (only for bone height in contact with implant surface). Conclusions: Within the limits of this animal experiment it is concluded that rhGDF-5 significantly enhances the amount and height of bone regeneration under membrane-protected critical size bone defects around implants. This study was supported by Scil Biomedicals. | ||
| Seq #295 - Bone Response to Surfaces/Scaffolds 1:30 PM-3:30 PM, Saturday, 28 June 2003 Svenska Massan J2 | ||
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