^{Objectives: To determine the effects of surface moisture on the bond strength of an ethanol/water based, Single Bond(SB); an acetone-based, One Step(OS); and a water-based, Syntac Single Component(SC) adhesive systems to dentin. Material and Methods: 90 third molars had a flat dentine surface exposed. The adhesives were applied to an area of 52 mm2 according to the manufacturers' instructions on either dry or rewetted surfaces (1.5, 2.5, 3.5, 4.0 or 4.5µl of distilled water), and composite crowns were constructed. After storage in distilled water (37°C-24h), the teeth were longitudinally sectioned in “x” and “y” directions to obtain sticks with cross-sectional area of 0.8 mm2 and tested in tension at 0.5 mm/min. The data was analyzed by two-way ANOVA, Tukey's test and regression analysis. Results: Significant main effects and interaction (p<0.0001) were detected. A quadratic relationship between the bond strength and the surface moisture was identified (R2 = 0.95, p<0.001). SB and OS showed a maximum bond strength (42.2±6.7 and 40.1±4.6MPa) that was similar (p=0.4996), however, obtained at different moisture degree (1.5 for SB and 3.5µl for OS). SC showed its maximum bond strength (27.7±3.9MPa) under 1.5µl. SB presented its higher bond strength at 1.5µl and that was higher than the bond strength obtained at any other degree of moisture (p<0.05). OS achieved its maximum bond strength at 3.5µl , however, that value was not different (p>0.05) from the values obtained at the range of 1.5-4.0µl. Similarly, highest bond strengths obtained with SC were not different (p>0.05) within the range of 0-3.5µl. Conclusions: All adhesive systems have a different moisture spectrum wherein higher bond strengths can be obtained. SB and SC performed better on a drier substrate, while OS showed better performance on wetter substrates. OS and SC had a broader range of moisture degree wherein maximum bond strength could be achieved.}

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