Objectives: The methacrylate derivatives have been widely used as the main component of the dentin adhesives though their negligible adverse effects on skin tissue have been reported. We reported the experimental dentin primer composed of glyceryl mono-methacrylate (GM) solution, which completely prevented the contraction gap formation of resin composite in a cylindrical dentin cavity. In addition, we reported the high-purity GM to avoid the possible side effect by the impurities. The purpose of this study was to evaluate the possibility of allergic reaction of the highly purified GM to the skin tissue by guinea-pig maximization test. Methods: The dentin primers were prepared by 35 % aqueous solution of 2-hydroxyethyl methacrylate (2-HEMA), 90.0%(GM), 96.0%(P-GM96) or 99.9%(P-GM99) purity guaranteed GM. Two Albino guinea-pigs (weighing 300-500g) were used in each group (2-HEMA, GM, P-GM96, and P-GM99). The skin reaction was evaluated according to the criteria of the International Contact Dermatitis Research Group (ICDRG). Results: The guinea-pigs that were sensitized by P-GM99 did not exhibit any positive response to challenge by P-GM96. The guinea-pigs that were sensitized by 2-HEMA, GM or P-GM96 did not indicate positive response to challenge by P-GM99. Conclusions: It was possible to conclude that the highly purified glyceryl mono-methacrylate may not cause the contact dermatitis and can be practiced safely as the dentin primer.

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