Objective: Bioactive glasses (BG) have been studied for several years and their mineralizing properties are well documented. BGs are potential filler components in mineralizing filling materials. The aim of this study was to evaluate in vitro dissolution of bioactive glass containing glass ionomer (GI) cements. Materials and Methods: Four different bioactive GI cements were made by mixing 10-wt% and 30-wt% of BG granules (<45mm) (Abmin Technologies Ltd, Turku, Finland) with autopolymerizing GI cement (GC Fuji II, GC, Japan), and with light curing resin-reinforced GI (LCGI) cement (Fuji II LC). Cements without BG granules were used as reference. Materials were immersed individually in 20ml of simulated body fluid (SBF) in water bath at 37°C. Materials were present in triplicate. Samples (20ml) were taken after 0, 1, 6, 24, 72, 168 and 336 hours and stored frozen (-20°C) until analyzed for Ca and Si ion concentrations. The quantitative analysis of ion concentration was made with a digital double beam spectrophotometer (Schimadzu 1601, Japan) using the appropriate wavelengths. Statistical evaluation was performed with MANOVA. Results: After 1 hour Si concentration of the SBF started to increase in all samples with BG. The Si concentration increased with time and it was highest in the LCGI with 30-wt% of BG (p<0.0001 at 336 hours). No change in Si concentrations was found in the reference materials. At 6 hours Ca concentrations of autopolymerizing GI cements were significantly higher than in LC materials, after which the concentrations decreased. After 72 hours Ca concentration started to increase in the LCGI with 30-wt% of BG and was significantly higher at 168 (p=0.0001) and at 336 (p=0.0007) hours than in other materials. Conclusions: BG containing GI cement is bioactive in simulated physiological conditions. Highest bioactivity was found in LC resin-reinforced materials.

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