| 1768 Effectiveness of Coronally Advanced Flaps With or Without the Addition of Enamel Matrix Derivative in the Treatment of Marginal Tissue Recession | ||
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M.A. CUEVA1, W.W. HALLMON2, M.E. NUNN3, E.P. ALLEN2, F. RIVERA-HIDALGO2, and F. ESLAMBOLTCHI2, 1Baylor College of Dentistry, Dallas, TX, USA, 2Baylor College of Dentistry, USA, 3Boston University, MA, USA Objectives: To evaluate the effectiveness of enamel matrix derivative (EmdogainŽ - Biora,Inc. Chicago,IL) in the treatment of marginal tissue recession. Methods: In order to evaluate the effectiveness of enamel matrix derivative in the treatment of marginal tissue recession, 15 eligible subjects with at least two contralateral sites with ³2 mm buccal recession were enrolled in this study. A split-mouth design was utilized with contralateral sites within each subject randomized to receive coronally-positioned flaps with or without the application of enamel matrix derivative so that each subject served as his own control. Fifty sites were included in the study, 25 test sites and 25 control sites, with subjects followed for 3 months after surgery. Percent root coverage, sensitivity, and tissue keratinization of test sites after 3 months were compared to control sites utilizing the method of generalized estimating equations (GEE) to accommodate multiple contralateral pairs within some subjects. Initial clinical parameters were considered for inclusion in GEE regression models to adjust for potential baseline differences. Results: Based on GEE regression, test sites had significantly greater root coverage after 3 months compared to control sites (p<0.001) with 88.4% root coverage for test sites compared to only 49.2% root coverage for control sites. Based on a GEE logistic regression model, control sites were significantly more likely to exhibit sensitivity after three months compared to test sites (OR=5.8, p<0.001). In addition, test sites had a somewhat greater increase in keratinized tissue after 3 months compared to control sites, although the increase was not statistically significant (p=0.078). Conclusions: The application of enamel matrix derivative to denuded root surfaces receiving coronally-positioned flaps significantly increases root coverage and significantly reduces post-operative sensitivity. In addition, preliminary results indicate that enamel matrix derivative may lead to a greater increase in keratinized tissue at treated recession sites.
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| Seq #170 - Biologic Response Modifiers and Tissue Formation 9:00 AM-11:00 AM, Friday, 8 March 2002 San Diego Convention Center Room 6E (Upper level) | ||
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