Biomimetic surface coatings on endosseous titanium implants are used to increase cellular reactions at implant/tissue interface, bone/implant interface attachment, decrease healing time and finally to improve the overall long-term implant therapy success. In addition, it can be used as a new coating method on oxidized titanium surfaces so that it can be made functional by covalent immobilization of biologic organic substance. Objective: In the current investigation DMP1 was used as the biologic organic substance due to its integrin-binding RGD domain and its potential functional role in mineralization. Methods: DMP1 was covalently bonded to polished titanium discs and the success of surface modification was demonstrated by X-ray photoelectron spectroscopy (XPS). Results: Interactive response of MC3T3-E1 cells to this chemically modified titanium surface was studied with respect to synthesis of bone-specific extracellular matrix proteins like bone-sialoprotein, osteopontin and alkaline phosphatase and cell proliferation. Conclusion: Specific interactions of bone cells with modified titanium surface could ultimately find applications for designing biomimetic dental implant surface. Supported By NIH grant DE 11657 and 2000-20001 American College of Prosthodontics and ESPE Fellowship in Geriatric Dentistry

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