Objective, this study aims to detect the histopathological changes in the clinically normal oral mucosa of healthy male smokers. Methods, the study includes 62 biopsies from healthy male smokers and 24 biopsies from healthy male non- smokers. All biopsies are taken from clinically normal sites which include: Attached gengiva and hard palatal mucosa ( masticatory mucosa ) , cheek and lip mucosa ( lining mucosa ). Results, the study refer that smoking accompanied with the following morphologic features and histopathological changes in the epithelium and connective tissue: increased keratinaization ( hyperorthokeratosis or hyperparakeratosis ) , acanthosis , irregular ret process , vocular degeneration and hydropic degeneration, cellular and intercellular edema, focal cell necrosis especially the palatal and cheek mucosa . also the specimens of smokers show more melanin pigmentation than non – smokers. Cigarette smoking induces peripheral vasoconstriction and may be accompanied with embolism formation. also most specimens of smokers show fibrinoid degeneration and fibrosis and generally collagen increase in the specimens of smokers relative to non – smokers . Conclusion, Cigarette smoking can produce many histopathological changes in the clinically normal oral mucosa through its local and systemic effects. Smoking affects on the biological functions of cells and tissues even there are not any abnormal clinical changes in the oral mucosa.

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